Archive: Future hope for Ménière’s, tinnitus and hearing loss

Posted By on January 12, 2015

As a conservative … politically, I probably don’t give enough credit to the Old Gray Lady for their often excellent articles covering content outside of politics. menieresdizzyThis weekend was no exception and I wanted to archive an article which has personal interest … and is something I’d like to look in to as an investor too. I’ve dealt with Ménière’s disease and its long term impact on my day to day life since the late 1990s. Thankfully, having just hearing loss and tinnitus is tolerable nowadays, but the vertigo in those early years was intolerable. Ugh, bad memories.

Auris Medical Hldng – EARS $3.61 1/9/2015 close
Otonony, Inc – OTIC   $33.25 – 1/9/2015 close

Companies are also working on drugs for tinnitus, in which sound is perceived without a source of the sound being present. Roughly 10 percent of American adults, or 25 million people, have experienced at least one episode lasting five minutes or more in the last year, according to the National Institute on Deafness and Other Communication Disorders.

Tinnitus can be caused by many things, including hearing loss. Treatments include behavioral therapy and devices that can mask the sound. But many of those just help people tolerate the condition, not get rid of it. Some drugs like steroids and lidocaine are used off label.

Auris is in late-stage trials of AM-101, a derivative of the anesthetic ketamine, which it hopes will dampen the aberrant signaling in the auditory nerve that is perceived as tinnitus. In a midstage trial, the drug, injected into the middle ear, was not more effective overall than a placebo. But a subset of patients whose tinnitus was caused by trauma or infection said the drug made the sound in their ears softer, less annoying and less disruptive of sleep.

Investors appear to be cautious given the challenges. Auris went public on Nasdaq in August at $6 a share, using the trading symbol EARS. The stock is now trading at about $4.

Otonomy’s stock, by contrast, has roughly doubled since its August initial public offering. That is perhaps because for now it is pursuing what might be more tractable problems.

When Mr. Lichter suffered his first attack of Ménière’s, he received steroids, a commonly used off-label treatment. But when the drug is injected into the middle ear, patients have to lie on their sides for 30 minutes and not swallow to try to keep the drug from draining into the throat through the Eustachian tube.

Otonomy, based in San Diego, developed a way to deliver the steroids as a gel that does not readily drain away after injection. The company has started the final stage of trials for the Ménière’s product. It hopes its first product — it will apply for regulatory approval in the first half of this year — could be a gel form of an antibiotic to be injected to treat middle ear infections, an alternative to ear drops.

Mr. Lichter said the intense bouts of vertigo, which left him bedridden two or three times a week, have not returned in four years. But he has constant ringing in his left ear and can barely hear through it.

Mr. Lichter, a managing director at Avalon Ventures in San Diego, said that although he had helped start 15 or 20 companies, “This is the one that is special to me.”

Full New York Times article

The Third Stage of Terrorism may be at our doorstep

Posted By on January 11, 2015

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This past week’s killings at the Charlie Hebdo offices needs to be a real eye-opener for those we elect to protect our citizens and nation. What many fear most is that this “radical Islamic terror attack” will be lost into the same hole as many of the previous terror attacks (or “workplace violence” if you are of the Obama mindset).richc_nytimes1_150110

What was different in the recent attack in Paris, is that the three four terrorists involved were radicalized and trained to efficiently target and kill. richc_nytimes2_150110Previous “gun oriented” attacks in the U.S. seemed to be less organized and more of the lone wolf style. The concern is that Al Qaeda and similar groups will build on this pattern as President Obama scales back the offensive War on Terror, closes Gitmo and reduces our intelligence gathering ability. We unfortunately sometimes need strong visuals in order to understand the enemy we face … and if beheadings do not do it for you, seeing cold blooded nature of their killings might – graphic video

Columnist and commentator Charles Krauthammer laid out the 2015 landscape frighteningly clear when he referenced this as the “third stage of the jihadist war against us.”  We know what we face, but do we have the resolve to fight?

  Charles Krauthammer on FN Special Report (mp3) January 9, 2015

Pension plans continue to fall behind as stock market gains

Posted By on January 10, 2015

One would think that a “rising tide lifts all boats” when it comes to gains for financial markets, but that is not the case for conservatively managed U.S. pension funds. The strong stock market returns during 2013 and 2014 have helped most individual investors recover from the 2008 financial collapse, so as long as they remained invested, but private pension funds actually lost ground. The trend is not pretty when looking at this last slow recovery from the Great Recession (Towers Watson graph below).

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According to a CNBC article citing Towers Watson, the “average private pension fund held about 80 percent of what it needs to cover payments. That’s down from 89 percent at the end of 2013 and represents an overall deficit among large corporate plans of about $343 billion, nearly double the shortfall a year earlier.”

towerswatsonlogoIn a previous interview with Dave Suchsland, a senior retirement consultant at Towers Watson, he stated, “We experienced another big year of pension de-risking in 2014, with significant lump sum buyout and annuity purchase activity. Given the change in funded status, we expect many plan sponsors will need to reevaluate their retirement plan strategies in 2015. Last year’s results surrendered most of the funded status gains earned in 2013. This year will most likely bring higher expense charges and unless there is an uptick in interest rates or equity market performance, eventually additional contribution requirements.”

LifeExpectancyIncreasing

So … should the Federal government (taxpayers) back pension funds? Winking smile
I wonder where Rick Santelli comes in on this idea (video)?

Parts arriving for the Mast Mate climbing ladder

Posted By on January 9, 2015

sailslugsAfter tinkering a little bit with my “climbing board” idea mentioned last month, I decided to spend a few more dollars and rig a Mast Mate climbing ladder with sail slugs to fit Encore’s mast. My liveaboard buddy Mark measured my Selden slugs and sent me a drawing so I ordered enough slugs to fit a web ladder.

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Along with the 42’  Mast Mate web ladder liosted on eBay, the deal included a toolbag and strap system called the Workbelt.

I’m anxious to get the new slugs installed and hoist the ladder up the mast, but thinking it might be a good idea to lose a few pounds before climbing the mast?
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Can downtown Toledo follow the urban revitalization trend?

Posted By on January 8, 2015

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The answer is YES if ProMedica’s President and CEO Randy Oostra has anything to say about it (video below). The company plans to move their corporate headquarters to the abandoned historic Toledo Edison Steam Plant property on the Maumee riverfront in a bold move which will play a significant role in boosting the local Toledo economy as well as attract businesses and more people to Promenade Park, but parking vs. green space is still being debated. For the health of the city, let’s hope both sides can come together and find an amiable solution.

Ohio cities, especially economically hard hit Toledo, need more local companies willing to partner with the community in order to bring back their cities and create an environment that attracts business to the community. Kudos to ProMedica and city leaders who are stepping forward and working to revitalize what once was a thriving city … and my family’s hometown.

We had a wonderful time with Katelyn and Drew

Posted By on January 7, 2015

DrewKatelynBrenda_FramedWedMy daughter Katelyn and her husband Drew were in town to visit this week and we pretended it was still the week of Christmas and exchanged a couple gifts. Brenda had already shipped a box of presents to them, but saved back a frame and print for them. It was an artistic photo taken down at Cincinnati’s Fountain Square from their wedding photos and put in an antique frame Brenda found at an estate sale. The framed canvas photo is beautiful.

We also received a couple gifts from them … and one that they brought home with them from our son Taylor.

 

One of the concerns was whether or not the larger frame was going to fit in Katelyn’s Nissan Juke. Drew and I had previously exchanged emails and measurements before they left Minnesota … and on paper it looked like it would fit. Still by the time we looked at the car and frame … I was not sure. Thankfully it “just” fit behind the seats and left them room for all the other stuff they were hauling. What a great visit!
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Extending the life of our old refrigerator

Posted By on January 6, 2015

Back in November I mentioned that I was “backpedaling” before buying a new refrigerator for our kitchen. We decided not to do anything before the holidays and so I figured rather than live with our ugly looking broken refrigerator that I could at least touch up the paint and put in a new light bulb. It looks a little better and might extend its life a little longer before forking over $1500 or so for a new one. I used on my my cheap Chinese eBay bulbs and a can of white appliance paint – big improvement except for the yellowed plastic and broken shelves.

PaintingRefrigerator RefrigeratorPainted

Cute animal photos are hard not to share … Yoga Bunny

Posted By on January 5, 2015

bunnyyogaPosting both a test post to update MyDesultoryBlog in order to set up the 2015 photo directories and because this is a cute yoga “bunny” photo for my daughter (and because of her rabbit Pumpy Umpy).

Katelyn enjoys Yoga and during our Christmas exchange and visit with them we talked about her new “hot Yoga” class which is a trend. From the sounds of it, it is physically challenging and something she enjoys. Really though, this is just a missed date filler post.

Oregon Ohio will make a name change for a day

Posted By on January 4, 2015

ohiostatesugarbowl2015This story hits home on two accounts …

1) Oregon, Ohio is a suburb of Toledo, Ohio where I went to school until moving to Sidney, Ohio in high school.

2) As an Ohio State fan and resident of Ohio my entire life, I’m excited to see my Buckeyes play the College Football National Championship game against  the Oregon Ducks. Both teams dominated in the Rose Bowl and Sugar Bowl games last week and should give all college football fans a great game. Go Bucks!

oregonohiomap

Oregon, Ohio, a suburb of Toledo, will temporarily change its name Jan. 12, the day of the inaugural College Football Playoff Championship Game, according to the Toledo Free Press.

No. 4 Ohio State, of course, plays No. 2 Oregon in the national title game in Arlington, Texas.

“We’ve heard about [the petition]. We’ve gotten calls. We’re going to do something with it,” Oregon City Administrator Michael Beazley told the paper.

Click here to view or sign the petition to change the city’s name. Interestingly, the petition also calls for Oregon’s Clay High School, which shares school colors (green and gold) with Oregon, to change its colors for the day.

The Toledo Free Press reports that the city will announce what the new name will be on Monday, Jan. 5.

Any recommendations, Ohio State fans?

LINK

The 40th annual LSSU list of banished words

Posted By on January 3, 2015

In keeping with tradition this time of year, Lake Superior State University (LSSU) has released their “banished words” for the 40th year.  The nominees totals “tens of thousands” but were narrowed down to 800 of the most annoying words and phrases in 2014 before giving them to the committee. Yes a few were appropriate for 2014 – Polar Vortex, Enhanced Interrogation and Skill Set – but there were a couple that I hadn’t heard before, like BAE and Friend-raising. Unfortunately once I said “Cra-Cra” aloud, I understood why it made the list – it made me “crazy” just to imagine it in a teenage voice … and now I can’t get it out of my head.

lssuart_adamraffaele2014
Adam Raffaele included this on the LSSU Banished Words Facebook page

Below is the LSSU list of 12 word or phrases so you can eliminate them from your vocabulary for 2015: Smile

CRA-CRA

That’s just crazy.

Early in 2014, Steve Kaufman of Houston, Tex., could be heard screaming, "I’ve only heard it twice and already know by the end of the year I’ll want to scream." 
"Short-form for ‘crazy’ and sometimes just one ‘cra.’ I hear kids (including my 6 yr. old) saying it all the time, e.g. ‘That snowstorm yesterday was ‘cra-cra.’" – Esther Proulx, Sault Ste. Marie, Mich.
"I’m sick of hearing myself say this! Must be banned!" – Roxanne Werly, Traverse City, Mich.

BAE

One of the top nominees.

"Meaning ‘before anyone else.’ How stupid! Stop calling your boyfriend ‘bae’." — Evie Dunagan, Manheim, Penn.

"It’s overused. I heard someone refer to their ramen noodles as ‘bae’! If I was putting someone ‘before anything else,’ I would respect them enough to use their name."  — S. Thoms, Sault Ste. Marie, Mich.
"The most annoying term of affection to show up in years. Also, the concept ‘before anybody else,’ developed AFTER the word became popular. Reason enough for it to be banned. – Blan Wright, Sugar Hill, Ga.

"A dumb, annoying word."  — James Becker, Holly, Mich.
"I’d rather be called ‘babe’ than ‘bae’ any day." — Alexsis Outwater, Bronson, Mich.

POLAR VORTEX

LSSU got a head start on this one last spring, when it burned a snowman named Mr. Polar Vortex during its 44th annual Snowman Burning.

"Wasn’t it called ‘winter’ just a few years ago? — Dawn Farrell, Kanata, Ont., Canada
"Enough with the over-sensationalized words to describe weather!" — A. Prescott, Oshawa, Ont., Canada
"I think most, if not all can agree that we would prefer to avoid the polar vortex in the future, both in name and in embodiment." — Christine Brace, Westminster, Md.
"What happened to ‘cold snap’? Not descriptive enough?" –Trevor Fenton, Edinburgh, U.K.

Kenneth Ross of Glastonbury, Conn., and Bob Priddy of Jefferson City, Mo., were among many who saw this storming in last January.

"Less than a week into the new year and it’s the most overused, meaningless word in the media," said Ross.

Priddy noted that it quickly jumped from the weather forecast to other areas, as he said he knew it would:  "Today’s St. Louis Post-Dispatch editorializes about a ‘political vortex.’"

HACK

Banished for over-use and mis-use.

"Suddenly things that once would have been called ‘tips’ are now being called ‘hacks.’ It can’t be because the one word is shorter or easier to say; and the actual accepted meanings of ‘hack’ have nothing to do with suggestions for doing tasks better or more efficiently — quite the opposite, really." – Sharla Hulsey, Sac City, Iowa.
"This word is totally over-used and mis-used. What they really mean is ‘tip’ or ‘short cut,’ but clearly it is not a ‘hack,’ as it involves no legal or ethical impropriety or breach of security." – Peter P. Nieckarz Jr., Sylva, N.C.

"I just received an e-mail for a book called ‘Marriage Hacks.’ I have seen articles about life hacks, home improvement hacks, car hacks, furniture hacks, painting hacks, work hacks and pretty much any other hack you can think of. There are probably even hacking hacks." – Chellsea Mastroine, Canton, Ohio.

"Life hack, this hack, that hack…stop with the hacks!" — Tim Jackson, Crystal Lake, Ill.

SKILL SET

"Why use two words when one will do? We already have a perfectly good word in ‘skills’ (ending with an s, not a z)." – Chip Lupo, Columbia, S.C.
"A skill is a skill — that is it. Phrases such as ‘I have the skill set to do that properly’ or anything resembling that phrase, shows the speaker is seriously lacking skills in the art of conversation. Please try this, ‘I have the skill… do you have the skills… this requires certain skills… he is very skilled… that was a skillful maneuver… See? No need for a skill set." – Stephanie Hamm-Wieczkiewicz, Litfield Park, Ariz.

SWAG

Many nominations over the years.

"The word ‘swag’ has become a shapeless, meaningless word used in various forms (such as ‘swaggy’) but with no real depth." – Bailey Anderson, Washington, Iowa.
"Whether it’s a ‘free gift’ (banished in 1988) or droopy clothing, this word is neither useful nor fancy." – Jeff Drake, Saint Albans, West Va.
"The word has become so overused that it is not ‘swag’ to not use the word ‘swag.’" – Devin, Farwell, Mich.
"Because I am tired of hearing swag to describe anything on the face of the planet. By the way, your website is so ‘swag.’" – Alex, Roanoke, Va.

FOODIE

Many nominations over the past several years. Is it a Michigan thing?

"It’s ridiculous. Do we call people who like wine ‘winies’ or beer lovers ‘beeries’?" – Randall Chamberlain, Traverse City, Mich.

"’Someone who enjoys food’ applies to everyone on Earth. What’s next? ‘Oh, I’m an airie; I just love to breathe.’ ‘Could we do it at 11, instead? I’m kind of a sleepie.’" – Andy Poe, Marquette, Mich.

"I crave good sleep, too, but that does not make me a sleepie. News flash: We ALL like food." – Graydeon DeCamp, Elk Rapids, Mich.
"I’ve heard of cooks and chefs, and gourmets and gourmands, but what the heck is a ‘foodie’? A person who likes food? A person who eats food? A person who knows what food is? Sounds like ‘foodie’ is a synonym for ‘everybody.’ Foodies around the world agree; let’s banish this term." – Steve Szilagyi, Mason, Mich.

CURATE / CURATED

"It used to have a special significance reserved mainly for fine art and museums. Now everything is curated. Monthly food and clothing subscription boxes claim to be finely ‘curated.’ Instead of abusing curated, why don’t they say what they really mean: ‘We did an online search and posted the first 25 items we found’ or the ‘curated selection of items in your box this month are a mix of paid placements and products that have failed to sell elsewhere.’" – Samantha McCormick, Kirkland, Wash.

"Example on the ‘Net today: ‘Get a curated box of high-end treats and toys (all tailored to the size of your pup) shipped right to your doggie door.’ – I have heard and read the word ‘curated’ far too many times this year." – Deb, Portland, Ore.
"A pretentious way of saying ‘selected.’ It’s enormously overused." – Kristi Hoerauf, San Francisco, Calif.

FRIEND-RAISING

"A horrible word that conflates the real meaning of friendship with usually hidden motivations to get at the other person’s pockets." – Mary Been, Sidnaw, Mich.
"The word suggests that we develop relationships not for the simple value of the person we call ‘friend,’ for the pleasure of being in a community of people and for the simple joys of sharing bonds of affection and common care, but that we instead develop these relationships out of some sort of expectation of a monetary reward." – Collette Coullard, Sault Ste. Marie, Mich.

ENHANCED INTERROGATION

"A shameful euphemism for torture." – David Bristol, Byron Center, Mich.

TAKEAWAY

"It’s used all too frequently on news programs, as in, ‘What is your ‘takeaway’ on (a given situation.’ ‘What is our ‘takeaway’ on Congress’ vote?’ ‘Is there any ‘takeaway’ on the recent riots?’ I have heard Jon Stewart use it. I’ve heard Charlie Rose use it, as well as countless numbers of news talking heads, usually for all the wrong reasons. For me, a takeaway is a sports term, where one team is controlling the ball (or puck) and the other steals it, or took it away – a ‘takeaway.’ In the U.K., ‘takeaway’ food is known as ‘to go’ here in the Colonies. – John Prokop, Oakland, Calif.

-NATION

A suffering sports suffix.

"Purely with reference to a specific teams’ fans, this word needs to go. It’s the following of a sports franchise, not a group seeking independence, recognition and legitimacy; Not even if it’s the Cubs." – Tim Wilcox, Sault Ste. Marie, Ont. Canada
"Although a devout Wisconsin sports fan, I do not belong to Packer-Nation, Badger-Nation, Phoenix-Nation, or Brewer-Nation. Further, I am not aware of any team or mascot that has the carrying capacity to be a nation." – Kelly Frawley, Waunakee, Wisc.

"Nothing more self-aggrandizing than sport team fans referring to themselves as a nation! What’s next? My team – Continent, World, Galaxy, Universe!" – Curt Chambers, Seattle, Wash.

"Both politics and sports teams have overused this n-word to describe their fans or viewers." – Ken Hornack, Ormond Beach, Fla.

Desultory - des-uhl-tawr-ee, -tohr-ee

  1. lacking in consistency, constancy, or visible order, disconnected; fitful: desultory conversation.
  2. digressing from or unconnected with the main subject; random: a desultory remark.
My Desultory Blog